Endocrine Abstracts

Introduction: Periadventitial adipose tissue has been implicated in vascular physiology and pathology, including atherosclerosis, through paracrine and endocrine mechanisms, mainly adipokine production. We investigated the expression of adipokines chemerin and adiponectin and their receptors CMKLR1 and T-cadherin, respectively, in human aortic arterial wall and periaortic fat as well as their correlation with aortic atherosclerosis.Methods: Paraffin embe...

Objective: To identify the optimal regime for physiological replacement in hypogonadism. We assessed the pharmacokinetics of 3 different dose-intervals for i.m. administration of the new parenteral formulation of testosterone undecanoate in castor oil (Schering AG Berlin).Methods: Ten hypogonadal subjects (primary n equals 4 or secondary n equals 6) with a baseline T at diagnosis of less than 7 nanomols per litre were recruited and randomly allocated int...

Objectives: SARS CoV-2 infections have been associated with the onset of classic subacute thyroiditis (SAT) or atypical SAT, observed in 10-15% of patients hospitalized for severe COVID19 disease (COV-A-SAT) and characterized by absence of neck pain, mild thyrotoxicosis associated with non-thyroidal illness syndrome and thyroiditis-like areas which may persist in the thyroid gland up to 12 months following SARS-CoV-2 infection, despite normalization of thyroid function. Little...

Introduction: T regulatory lymphocytes (Tregs) are defined as CD4+CD25high T lymphocytes and are thought to regulate immune tolerance. The Foxp3 protein level in Tregs is proportional to CD25 protein surface expression and regulatory function, but inversely proportional to IL-7R (CD127) level, the receptor for the growth and survival of T cells. We investigated possible differences in Tregs between newly diagnosed type 1 diabetes (DM1) patients and contro...

BackgroundMultiple neuroendocrine neoplasia type 1 is a rare, heterogeneous genetic disorder with an autosomal dominant inheritance, predisposing to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localisation, age of onset and clinical aggressiveness, even between affected members of the same family. We report a heterogenic phenotype of the MEN1 variant c.[781C > T] (LRG_509t1) previously reporte...

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...

Non-functional pituitary adenomas (NFPA) are non-hormone secreting pituitary tumours while growth hormone-secreting pituitary adenomas (GHPA) are active pituitary tumours causing acromegaly. Since immunotherapy is becoming the preferred therapeutic strategy in cancers, understanding the diversity of immune cells infiltrating the tumour microenvironment is warranted. However, little is known about the immune landscape of pituitary tumours. We validated an acoustic-assisted hydr...

Introduction: Graves’ disease (GD) management in Indonesia are generally preceded by administration of antithyroid drugs. Antithyroid drug delivery requires a long time to achieve remission, even more than 50% of patients who had remission can recur after antithyroid medication is stopped. The purpose of this study was to determine the role of CTLA-4 gene and regulatory T cells against recurrence in patients GD in Indonesia.Methods: The study was co...

Osteogenesis imperfecta (OI) is a heritable skeletal disorder caused by defective bone formation. OI type V (MIM#:614757) develops due to mutation in the IFITM. Mutation c.-14C >T in the IFITM5 is more common whereas only five reported patientshave a c.119C >T mutation. Patients with IFITM5:c.119C >T mutation usually have low-traumatic fractures in the prenatal period of development, severe limb and chest deformities, short height, verteb...

Introduction: The 25hydroxyvitamin(OH)D deficiency has been linked to the risk of postmenopausal fractures and osteoporosis. In Colombia,the prevalence of 25(OH)vitaminD deficiency is high, reaching more than 53% of the total population. It can be stated that hip fracture is one of its most feared complications, with a high risk of mortality and morbidity,which can affect even osteopenic patients. The objective of this study is to assess modifications in hip T-score (using dua...